1 00:00:06,828 --> 00:00:11,387 If you lined up all the blood vessels in your body, 2 00:00:11,387 --> 00:00:15,429 they'd be 95,000 kilometers long 3 00:00:15,429 --> 00:00:21,984 and everyday, they carry the equivalent of over 7,500 liters of blood, 4 00:00:21,984 --> 00:00:27,508 though that's actually the same four or five liters recycled over and over, 5 00:00:27,507 --> 00:00:30,041 delivering oxygen, and precious nutrients 6 00:00:30,041 --> 00:00:34,960 like glucose and amino acids to the body's tissues. 7 00:00:34,960 --> 00:00:40,240 All that blood exerts a force on the muscular walls of the blood vessels. 8 00:00:40,240 --> 00:00:43,066 That force is called blood pressure, 9 00:00:43,066 --> 00:00:46,999 and it rises and falls with the phases of the heartbeat. 10 00:00:46,999 --> 00:00:48,995 It's highest during systole, 11 00:00:48,994 --> 00:00:52,853 when the heart contracts to force blood through the arteries. 12 00:00:52,853 --> 00:00:55,195 This is your systolic blood pressure. 13 00:00:55,195 --> 00:00:57,693 When the heart is at rest between beats, 14 00:00:57,694 --> 00:01:02,435 blood pressure falls to its lowest value, the diastolic pressure. 15 00:01:02,435 --> 00:01:05,861 A typical healthy individual produces a systolic pressure 16 00:01:05,861 --> 00:01:10,347 between 90 and 120 millimeters of mercury, 17 00:01:10,347 --> 00:01:14,109 and diastolic pressure between 60 and 80. 18 00:01:14,109 --> 00:01:19,572 Taken together, a normal reading is a bit less than 120 over 80. 19 00:01:19,572 --> 00:01:21,891 The blood traverses the landscape of the body 20 00:01:21,891 --> 00:01:24,977 through the pipes of the circulatory system. 21 00:01:24,977 --> 00:01:26,477 In any plumbing system, 22 00:01:26,477 --> 00:01:29,945 several things can increase the force on the walls of the pipes: 23 00:01:29,944 --> 00:01:31,555 the properties of the fluid, 24 00:01:31,555 --> 00:01:32,707 extra fluid, 25 00:01:32,707 --> 00:01:34,760 or narrower pipes. 26 00:01:34,760 --> 00:01:36,190 So if the blood thickens, 27 00:01:36,189 --> 00:01:41,436 a higher pressure is needed to push it, so the heart will pump harder. 28 00:01:41,436 --> 00:01:44,781 A high-salt diet will lead to a similar result. 29 00:01:44,781 --> 00:01:46,932 The salt promotes water retention, 30 00:01:46,933 --> 00:01:51,397 and the extra fluid increases the blood volume and blood pressure, 31 00:01:51,397 --> 00:01:54,456 and stress, like the fight or flight response, 32 00:01:54,456 --> 00:01:58,365 releases hormones, like epinephrine and norepinephrine 33 00:01:58,364 --> 00:02:00,549 that constrict key vessels, 34 00:02:00,549 --> 00:02:05,210 increasing the resistance to flow and raising the pressure upstream. 35 00:02:05,210 --> 00:02:08,771 Blood vessels can usually handle these fluctuations easily. 36 00:02:08,771 --> 00:02:13,520 Elastic fibers embedded in their walls make them resilient, 37 00:02:13,520 --> 00:02:18,605 but if your blood pressure regularly rises above about 140 over 90, 38 00:02:18,605 --> 00:02:21,846 what we call hypertension, and stays there, 39 00:02:21,846 --> 00:02:23,969 it can cause serious problems. 40 00:02:23,969 --> 00:02:26,693 That's because the extra strain on the arterial wall 41 00:02:26,693 --> 00:02:28,455 can produce small tears. 42 00:02:28,455 --> 00:02:30,618 When the injured tissue swells up, 43 00:02:30,618 --> 00:02:33,213 substances that respond to the inflammation, 44 00:02:33,213 --> 00:02:36,582 like white blood cells, collect around the tears. 45 00:02:36,582 --> 00:02:41,014 Fat and cholesterol floating in the blood latch on, too, 46 00:02:41,014 --> 00:02:43,586 eventually building up to form a plaque 47 00:02:43,586 --> 00:02:47,694 that stiffens and thickens the inner arterial wall. 48 00:02:47,693 --> 00:02:50,497 This condition is called atherosclerosis, 49 00:02:50,497 --> 00:02:52,645 and it can have dangerous consequences. 50 00:02:52,645 --> 00:02:56,691 If the plaque ruptures, a blood clot forms on top of the tear, 51 00:02:56,692 --> 00:02:59,605 clogging the already narrowed pipe. 52 00:02:59,604 --> 00:03:00,921 If the clot is big enough, 53 00:03:00,921 --> 00:03:06,745 it can completely block the flow of oxygen and nutrients to cells downstream. 54 00:03:06,745 --> 00:03:08,373 In vessels that feed the heart, 55 00:03:08,373 --> 00:03:10,400 that will cause a heart attack, 56 00:03:10,401 --> 00:03:14,891 when oxygen-deprived cardiac muscle cells start to die. 57 00:03:14,891 --> 00:03:17,575 If the clot cuts off blood flow to the brain, 58 00:03:17,575 --> 00:03:20,265 it causes a stroke. 59 00:03:20,265 --> 00:03:22,990 Dangerously clogged blood vessels can be widened 60 00:03:22,991 --> 00:03:25,797 by a procedure called an angioplasty. 61 00:03:25,796 --> 00:03:28,870 There, doctors thread a wire through the vessel 62 00:03:28,870 --> 00:03:30,829 to the obstructed site, 63 00:03:30,829 --> 00:03:34,903 and then place a deflated balloon catheter over the wire. 64 00:03:34,902 --> 00:03:38,894 When the balloon is inflated, it forces the passageway open again. 65 00:03:38,894 --> 00:03:41,832 Sometimes a rigid tube called a stent 66 00:03:41,832 --> 00:03:45,117 is placed in a vessel to held hold it open, 67 00:03:45,117 --> 00:03:46,746 letting the blood flow freely 68 00:03:46,747 --> 00:03:50,280 to replenish the oxygen-starved cells downstream. 69 00:03:50,280 --> 00:03:53,911 Staying flexible under pressure is a tough job for arteries. 70 00:03:53,911 --> 00:03:56,673 The fluid they pump is composed of substances 71 00:03:56,673 --> 00:03:59,277 that can get sticky and clog them, 72 00:03:59,277 --> 00:04:02,929 and your typical healthy heart beats about 70 times a minute, 73 00:04:02,930 --> 00:04:07,723 and at least 2.5 billion times during an average lifetime. 74 00:04:07,723 --> 00:04:10,899 That may sound like an insurmountable amount of pressure, 75 00:04:10,899 --> 00:04:15,108 but don't worry, your arteries are well suited for the challenge.